Brava Diagnostics is seeking seed financing to develop our cardiac marker assays. The table below summarizes indications and actions that physicians may take, guided by test results.

Intended UseAction
Chest Pain Assessment
Aid in the diagnosis of heart attack in the emergency department• Administer "clot buster"
• Send patient to catheterization lab
• Observation in chest pain unit/ED
• Discharge
Heart Failure Assessment
Aid in the diagnosis and risk assessment of heart failure in the EDAid in differential diagnosis, staging and prognosis to guide intervention

Chest Pain Assessment

Prevalence

  • ~5 million Americans have coronary heart disease (CHD), the syndrome that leads to heart attack.

Incidence

  • The American Heart Association estimates that an American will have a heart attack every 40 seconds.
  • The National Heart, Lung and Blood Institute (NHLBI) estimates that 695,000 Americans will have a new coronary event and ≈325,000 will have a recurrent event each year.

Mortality

  • CHD was an underlying cause of death in ≈1 of every 7 deaths in the U.S. in 2013.
  • CHD contributed to 530,989 deaths.
  • Approximately 36% of the people who experience a coronary event in a given year will die of it, and ≈14% who experience a heart attack will die of it.

Cost

  • The estimated direct and indirect cost of CHD in 2012 to 2013 was $199.6 billion
  • Heart attack ($11.5 billion) and CHD ($10.4 billion) were 2 of the 10 most expensive hospital principal discharge diagnoses.
  • Between 2013 and 2030, medical costs of CHD (real 2010$) are projected to double

We believe that the LightDeck System will meet the performance characteristics required by the American College of Cardiology guidelines, deliver results in under 20 minutes and enable improved assessment and management of chest pain patients.

Heart Failure Assessment

Prevalence

  • Approximately 6.5 million Americans have heart failure.
  • Projections show that the prevalence will increase 46% from 2012 to 2030, resulting in >8 million people with heart failure.

Incidence

  • There are 960,000 new heart failure cases annually.

Mortality

  • 1 in 8 deaths has heart failure mentioned on the death certificate. In 2014, heart failure any-mention mortality was 308,976.
  • The death rate remains high: ≈50% of people diagnosed with heart failure will die within 5 years.

Cost

  • In 2012, total cost for heart failure was ~$30.7 billion. Of this total, 68% was attributable to direct medical costs.
  • By 2030, the total cost will increase almost 127% to $69.7 billion.

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