Brava Diagnostics is seeking financing to fund development of our high-sensitivity troponin assay.

This sort video gives an overview of current care pathways for managing chest pain in an emergency department and potential impact of adopting high-sensitivity troponin assays.

The table below summarizes indications and actions that physicians may take, guided by test results.

Intended UseAction
Chest Pain Assessment
Aid in the diagnosis of heart attack in the emergency department• Administer "clot buster"
• Send patient to catheterization lab
• Observation in chest pain unit/ED
• Discharge
Heart Failure Assessment
Aid in the diagnosis and risk assessment of heart failure in the ED• Rule-in or rule-out heart failure
• Guide treatment selection and intensity
• Risk-stratify patient

Chest Pain Assessment

Prevalence

According to the 2019 American Heart Association Statistical Update for Heart Disease and Stroke:

  • In 2016, 18.2 million Americans had coronary heart disease (CHD), the syndrome that leads to heart attack.
  • 8.4 million Americans have a history of heart attack.

Incidence

  • There were 8 million visits to emergency departments for chest pain in the U.S. in 2016.
  • The American Heart Association estimates that an American will have a heart attack every 40 seconds.
  • 1,055,000 new or recurrent heart attacks occur each year.

Mortality

  • CHD contributed to 533,126 deaths and heart attacks caused 149,615 deaths.
  • Approximately 35% of the people who experience a coronary event in a given year will die of it, and ≈14% who experience a heart attack will die of it.

Cost

  • The estimated direct and indirect cost of CHD in 2014 to 2015 was $218.7 billion.
  • Heart attack ($12.1 billion) and CHD ($9 billion) were 2 of the 10 most expensive hospital principal discharge diagnoses.
  • Between 2013 and 2030, medical costs of CHD are projected to double.

We believe that the LightDeck System will meet the sensitivity and precision characteristics required by the American College of Cardiology guidelines, deliver results in under 15 minutes and enable improved assessment and management of chest pain patients.

Heart Failure Assessment

Prevalence

According to the 2019 American Heart Association Statistical Update for Heart Disease and Stroke:

  • Approximately 6.2 million Americans have heart failure. This represents an increase of 5.7 million people since 2009-2012 surveys.
  • Projections show that the prevalence will increase 46% from 2012 to 2030, resulting in >8 million people with heart failure.

Incidence

  • There are 1 million new heart failure cases annually.

Mortality

  • In 2016, heart failure was the underlying cause in 78,356 deaths.

Cost

  • In 2012, total cost for heart failure was ~$30.7 billion. Of this total, 68% was attributable to direct medical costs.
  • By 2030, the total cost will increase almost 127% to $69.7 billion.

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